Fig. 1. Enterovirus surveillance reports in Taiwan since 2005 and phylogenetic tree of Taiwanese EV-A71 full-genome sequences.

a Percentages of enterovirus infections since 2005, including EV-A71 (marked in red), six CV types (A2, A4, A5, A6 A10, and A16 in different colors), EV-B (purple), and other species (gray) in Taiwan. EV-B included CV types (B1–6 and A9) and echovirus types 3, 6, 11, 18, and 30. Counts of total cases reported in each year are also shown in parentheses. b Counts of severe complications are further summarized. c Compressed ML tree of Taiwanese strains in various subgenotypes (A, B0–5, and C1–5). Significant bootstrap support values greater than 70% are indicated at major nodes. d B5 and e C4 subtrees are shown. The tip labels of the 63 strains in B5 and C4 sequenced in this study are colored in red