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. 2018 Jun 21;7:111. doi: 10.1038/s41426-018-0107-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Recombination among the currently circulating CVs was examined. Using EV-A71 B3 as the reference strain, a single crossover at the P1/P2 boundary was detected by SimPlot (left panel) and Bootscan (right panel) analyses by querying (a) CV-A2, (b) CV-A6, (c) CV-A8, and d CV-A12. The roles of (e) EV-A71 C4 recombined with CV-A2 and f intertypic recombination of CV-A2 and CV-A4 are further examined. The references used in each analysis are marked in different colors, and coding nucleotide positions corresponding to the viral genome are indicated