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. 2018 Jun 21;8:9448. doi: 10.1038/s41598-018-27881-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Attenuated adverse ventricular remodeling after FG-aided, epicardial placement of MSCs in the ICM rat heart. (a) Cross-sectional area of cTnT cardiomyocyte was measured using immunohistolabeling samples at day 28 post-treatment. Scale bar = 50 μm. (b) Post-MI interstitial fibrosis in the peri-infarct area was assessed by picrosirius red staining at day 28 post-treatment. Scale bar = 100 μm. (c) Accumulation of CD163⁺ cells (green) in the myocardium at day 7 was most evident in the FG-MSC group. Scale bar = 100 μm. n = 6 hearts in each group. *p < 0.05 vs. the Sham group, ^† p < 0.05 vs. IM-MSC group. ^§ p < 0.05 vs. FG-Cont group.