Table 1.

Pre- and post-treatment cardiac function assessed by echocardiography and cardiac catheterization.

Echocardiography pre-treatment (=4 weeks after MI)
Group	n	HR (bpm)	LVEF (%)	LVFS (%)	LVDs (mm)	LVDd (mm)
Sham	12	390.5 ± 8.7	36.2 ± 1.3	18.2 ± 0.7	6.9 ± 0.2	8.3 ± 0.1
IM-MSC	13	399.0 ± 6.7	35.8 ± 1.4	18.0 ± 0.8	7.0 ± 0.1	8.5 ± 0.1
FG-MSC	13	392.6 ± 6.8	35.8 ± 1.0	18.2 ± 0.5	6.9 ± 0.2	8.4 ± 0.2
FG-Cont	12	383.6 ± 7.9	35.4 ± 1.2	17.7 ± 0.7	6.7 ± 0.1	8.4 ± 0.1
Echocardiography at 4 weeks after MSC therapy (=8 weeks after MI)
Group	n	HR (bpm)	LVEF (%)	LVFS (%)	LVDs (mm)	LVDd (mm)
Sham	12	394.7 ± 8.3	33.3 ± 1.5	16.3 ± 0.8	7.7 ± 0.2	9.2 ± 0.2
IM-MSC	13	393.1 ± 6.6	38.9 ± 1.7*†	20.2 ± 1.0*†	7.1 ± 0.2*†	8.9 ± 0.2
FG-MSC	13	399.6 ± 6.2	43.0 ± 1.4*†§	23.2 ± 0.8*†§	6.6 ± 0.1*†§	8.6 ± 0.2*
FG-Cont	12	387.6 ± 8.3	34.2 ± 1.6	16.7 ± 1.0	7.5 ± 0.2	9.0 ± 0.2
Cardiac catheterization at 4 weeks after MSC therapy (=8 weeks after MI)
Group	n	HR (bpm)	Dev Pressure (mmHg)	LVEDP (mmHg)	Max dP/dt (mmHg/s)	Min dP/dt (mmHg/s)
Sham	12	380.5 ± 2.6	106.2 ± 3.8	10.2 ± 2.0	6,463 ± 265	−6,484 ± 234
IM-MSC	13	391.7 ± 4.2	120.1 ± 4.0*	8.7 ± 1.2	7,735 ± 275*†	−6,950 ± 198*
FG-MSC	13	388.7 ± 5.9	138.5 ± 3.9*†§	6.3 ± 0.8*†§	8,044 ± 268*†§	−7,705 ± 262*†§
FG-Cont	12	379.8 ± 4.0	111.9 ± 3.7	9.2 ± 1.3	6,876 ± 321	−6,773 ± 314

Sham group; Sham surgery (open chest only) at 4 weeks after MI

IM-MSC group; intramyocardial MSC injection at 4 weeks after MI

FG-MSC group; epicardial placement of FG incorporating MSC at 4 weeks after MI

FG-Cont group; epicardial placement of FG without MSC at 4 weeks after MI

HR, heart rate; bpm, beat per minute; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVDs, left ventricular end-systolic dimension; LVDd, left ventricular end-diastolic dimension; Dev Pressure, left ventricular developed pressure; LVEDP, left ventricular end-diastolic pressure.

*p < 0.05 vs. Sham group, ^† p < 0.05 vs ^. FG-Cont group, ^§ p < 0.05 vs. IM-MSC group, Mean ± SEM.