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. 2018 Jun 21;8:9482. doi: 10.1038/s41598-018-27210-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distinct gene expression profiles in breast-cancer cell lines co-cultured with 3T3-L1 adipocytes. Rank-based heatmaps displaying the top up- and down-regulated genes (≥2.0-fold) in the breast cancer cell lines (a) MCF7, (b) T47D and (c) MDA-MB-231 co-cultured with 3T3-L1 adipocytes. Red indicates up-regulation in co-culture; blue indicates down-regulation; see Supplemental Tables S2–S4 for absolute fold-changes. (d) Venn-Diagram representation of significantly differentially expressed genes (≥1.3-fold expression differences) in the respective cell lines.