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. 2018 Jun 21;8:9481. doi: 10.1038/s41598-018-25994-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PMCs were overlaid with fibrin via incubation with a fibrinogen and thrombin mixture for 2, 4 and 8 hr. (A) The effects of QLT-0267 on cytokine expression were evaluated in triplicate by RT-PCR. The relative expression of (B) IL-6, (C) IL-1β, (D) TNFα, (E) VEGF-A, (F) TGFβ1 and (G) VEGF-C vs. GAPDH are presented as a percentage of increase over untreated PMCs (NT). The line between NT and 0 μM of QLT-0267 was removed (marked by a dotted line), and the original full-length images are presented in Supplementary Figure 4S. *P < 0.05 vs. NT; ^#P < 0.05 vs. 0 μM of OLT-0267 at the same incubation time.