Fig. 1.

a Schematic illustration of the generation of a water-soluble and systemically injectable nanomedicine co-encapsulating two anticancer agents, cyclosporin A (CsA) and Gefitinib (Gef), using the amphiphilic block copolymer polyethylene glycol-block-poly(lactide) (PEG-PLA). The chemical structures of CsA, Gef, and PEG-PLA are also presented. b Transmission electron microscopy (TEM) morphology of drug-formulated nanoparticles (NPs) (termed CsA-NPs, Gef-NPs, and CsA/Gef-NPs for formulations including CsA, Gef, and both CsA and Gef, respectively). Scale bars represent 100 nm. c Size distribution of NPs as determined by dynamic light scattering (DLS). d DLS analysis indicated that these NPs were small in size and had a narrow size distribution. Zeta potentials are also provided