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. 2018 Jun 22;3:16. doi: 10.1038/s41392-018-0019-4

Fig. 6.

Fig. 6

CsA inhibits Gef-induced STAT3 activation when co-delivered by NPs in two NSCLC xenograft models. Scale bars represent 50 μm. ac Immunohistochemical (IHC) staining for p-STAT3 in paraffin-embedded tissue sections, quantitative IHC results, and western blot results for p-STAT3/Bcl-2 in PC-9-GR xenograft-bearing mice. df The same assays were conducted for H1975 xenografts. The magnification of the IHC images is 400×. c, f Tumor tissue levels of c-PARP, an apoptosis marker, in both PC-9-GR and H1975 xenograft tumors were also detected by immunoblotting