Fig. 6.
CsA inhibits Gef-induced STAT3 activation when co-delivered by NPs in two NSCLC xenograft models. Scale bars represent 50 μm. a–c Immunohistochemical (IHC) staining for p-STAT3 in paraffin-embedded tissue sections, quantitative IHC results, and western blot results for p-STAT3/Bcl-2 in PC-9-GR xenograft-bearing mice. d–f The same assays were conducted for H1975 xenografts. The magnification of the IHC images is 400×. c, f Tumor tissue levels of c-PARP, an apoptosis marker, in both PC-9-GR and H1975 xenograft tumors were also detected by immunoblotting