Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 21;8:9474. doi: 10.1038/s41598-018-27718-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Consequences of metastatic seeding on primary tumor growth dynamics. (A) Simulated tumor growth of a breast tumor (with low growth rate σ = 0.03). (B) Seeding of a slightly faster-growing metastasis in the lung (σ = 0.035) at time t = 200 days yields accelerated growth of the primary breast tumor. (C) Metastatic seeding re-routes effector cells from the primary breast tumor to the lung metastasis due to its higher blood flow fraction. (D) Simulated tumor growth of a lung tumor (with growth rate σ = 0.035). (E) Seeding of a slightly slower-growing metastasis in the breast (σ = 0.03) at time t = 200 days yields transient decay followed by decelerated growth of the primary lung tumor. (F) Metastatic seeding increases the total systemic number of effector cells, and increases the number of immune cells extravasating at the primary lung tumor due to its higher blood flow fraction.