Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 21;8:9474. doi: 10.1038/s41598-018-27718-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Abscopal responses after focal radiation. Abscopal responses in the untreated tumor are indicated by a green (+). Accelerated growth of an untreated metastatic tumor (negative abscopal response) is indicated by a red (−). A primary tumor grows and seeds a metastasis at time t = 200 days. Seeding order does not influence the respective tumor volumes at radiation time t = 800. (A,B) Radiation to the lung tumor with higher blood flow fraction. Irradiation of the lung tumor allows the previously redirected immune response to return to its site of activation in the breast, inducing a prolonged abscopal response here. (C,D) Radiation to the breast tumor with lower blood flow fraction. Irradiation of the breast tumor yields an initial, transient abscopal effect. At onset of radiation, the immune cell population initially increases at both sites due to radiation-induced immunity. As the breast tumor volume decreases, fewer immune cells are stimulated and the lung tumor is return to its intrinsic faster growth. This yields a transient decay followed by decelerated growth of the primary lung tumor (Fig. 2D).