Fig. 7.

Invading cancer cells display plastic EMT, but fail to induce CD44 or show properties of CGC. a Sites of airway invasion show inflammation (arrow). b Sites of tumor invasion are Tgf-β1-rich and remain Pten−. c Zeb1 is re-induced in tumor cells at sites of airway invasion. d E-cadherin (E-cad) is repressed in tumor cells at sites of airway invasion, but it is maintained in airway epithelial cells (arrow). e Higher power view of Zeb1+, E-cad− tumor cells invading an airway. The arrow indicates E-cad+ airway epithelial cells. f Invading tumor cells continue to be CD44^lo. g Quantification of cell morphology, expression, and division patterns in invasive and non-invasive tumors. n = 18 at P220. Bars are 50 μm