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. 2018 Jun 21;8:9442. doi: 10.1038/s41598-018-27782-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of IFIH1 rs1990760 genotypes with IL-18 and granzyme B serum levels. Serologic profile of SLE patients with different genotype of IFIH1 from 155 SLE patients (84 CC, 54 CT and 17 TT genotype for rs1990760). TT genotype carriers at rs1990760 in IFIH1 had lower serum levels of IL-18 and granzyme B than the CC and CT genotype carriers (P < 0.001, respectively). (a) IL-18 (pg/ml): CC genotype 234.13 (167.07,349.07), CT genotype 252.51 (203.74,347.16) and TT genotype 125.89 (92.33,162.06) for rs1990760, respectively. (b) Granzyme B (pg/ml): CC genotype 6.85 (5.19,16.24), CT genotype 8.49 (4.15,20.30) and TT genotype 3.53 (2.37,3.92) for rs1990760, respectively. The results represent the median and interquartile of IL-18 and granzyme B levels.