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. 2018 Jun 21;8:9484. doi: 10.1038/s41598-018-27649-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Variable dose-dependent response of TNTs forming after exposure to the chemotherapeutic drug doxorubicin. (A) Representative images of TNTs transmitting autofluorescing (red) doxorubicin between S2013 cells. Images were taken using a Zeiss Axio widefield microscope. Scale bars = 50 μm. (B,C) Scatter-plot graph depicting the median number of TNTs/cell (TNT index) over time, comparing results for the S2013 (Panel B) and MIA PaCa-2 (Panel C) cell lines after exposure to six concentrations of doxorubicin. This experiment was done in triplicate, with a sample size of 18 fields of view per dose/per time point.