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. 2018 Jun 21;8:9484. doi: 10.1038/s41598-018-27649-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TNTs act as a direct conduit for intercellular transfer and redistribution of the chemotherapeutic drug doxorubicin. (A) TNT formation and intercellular transfer of doxorubicin between S2013 pancreatic adenocarcinoma cells. (B) Composite of serial images from time-lapse microscopy demonstrating intercellular transfer of doxorubicin from a chemoresistant ovarian cancer cell (SKOV3) to a chemosensitive cell (A2780) via a TNT, resulting in cell death of the chemosensitive cell. Images were taken every 15 minutes for 24 hours using a wide-field Zeiss Axio200M microscope.