Table 3.
Associations between lifestyle factors and colorectal primary tumor methylation of NEUROG1 by race.
| Group | NEUROG1Cut Point (%) | n (%)High | Fruits | Vegetables | Folate | NSAIDs | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |||
| AA (n = 192) | 10 | 140 (73) | 1.28 | 0.52, 3.15 | 1.51 | 0.57, 4.03 | 0.86 | 0.30, 2.44 | 1.16 | 0.50, 2.73 |
| 15 | 115 (60) | 0.95 | 0.44, 2.05 | 0.85 | 0.37, 1.92 | 1.24 | 0.50, 3.10 | 1.02 | 0.48, 2.14 | |
| 20 | 98 (51) | 1.12 | 0.52, 2.39 | 0.98 | 0.43, 2.20 | 0.95 | 0.39, 2.34 | 1.23 | 0.59, 2.56 | |
| 25 | 76 (40) | 0.74 | 0.34, 1.64 | 1.01 | 0.44, 2.34 | 0.89 | 0.35, 2.26 | 1.13 | 0.54, 2.39 | |
| 30 | 58 (30) | 0.67 | 0.29, 1.56 | 1.30 | 0.54, 3.09 | 1.10 | 0.42, 2.96 | 0.73 | 0.32, 1.65 | |
| 35 | 43 (22) | 0.49 | 0.19, 1.28 | 1.59 | 0.62, 4.06 | 1.19 | 0.40, 3.54 | 0.65 | 0.26, 1.64 | |
| 40 | 27 (14) | 0.27 | 0.08, 0.94 | 2.26 | 0.78, 6.50 | 2.25 | 0.64, 8.00 | 0.96 | 0.34, 2.71 | |
| 45 | 18 (9) | 0.40 | 0.10, 1.55 | 1.63 | 0.47, 5.65 | 2.09 | 0.50, 8.82 | 0.61 | 0.16, 2.32 | |
| 50 | 9 (5) | 0.80 | 0.14, 4.41 | 5.03 | 0.98, 25.98 | 1.35 | 0.20, 9.16 | 1.25 | 0.23, 6.82 | |
| EA (n = 234) | 10 | 161 (69) | 2.11 | 0.92, 4.85 | 1.20 | 0.61, 2.37 | 0.58 | 0.28, 1.22 | 1.10 | 0.56, 2.17 |
| 15 | 141 (60) | 2.73 | 1.24, 6.01 | 1.44 | 0.75, 2.76 | 0.51 | 0.25, 1.05 | 1.09 | 0.58, 2.08 | |
| 20 | 119 (51) | 2.51 | 1.21, 5.21 | 1.36 | 0.73, 2.55 | 0.52 | 0.25, 1.04 | 0.80 | 0.43, 1.49 | |
| 25 | 97 (41) | 2.83 | 1.39, 5.79 | 1.26 | 0.67, 2.38 | 0.62 | 0.30, 1.28 | 0.79 | 0.42, 1.50 | |
| 30 | 75 (32) | 3.44 | 1.66, 7.13 | 0.96 | 0.49, 1.88 | 0.68 | 0.32, 1.46 | 0.63 | 0.31, 1.25 | |
| 35 | 58 (25) | 2.68 | 1.26, 5.70 | 1.07 | 0.53, 2.18 | 0.62 | 0.28, 1.40 | 0.65 | 0.31, 1.36 | |
| 40 | 43 (18) | 1.96 | 0.85, 4.52 | 1.10 | 0.50, 2.43 | 1.00 | 0.41, 2.41 | 0.46 | 0.19, 1.13 | |
| 45 | 27 (12) | 1.55 | 0.52, 4.60 | 2.08 | 0.83, 5.23 | 0.44 | 0.14, 1.44 | 0.46 | 0.15, 1.44 | |
| 50 | 17 (7) | 0.88 | 0.21, 3.69 | 4.47 | 1.44, 13.90 | 0.63 | 0.16, 2.42 | 1.01 | 0.29, 3.51 | |
N (%) High = number (%) with NEUROG1 methylation at or above the respective cut point. Each row represents 1 model with a dependent variable of dichotomous methylation status (high versus low) as defined by the given cut point and independent variables of age, sex, and lifestyle variables (fruits, vegetables, folate, NSAIDS). Lifestyle variables were dichotomized (high versus low) at the 75th percentile based on the distribution in the overall sample (AA and EA combined).
AA = African Americans, EA = European Americans, NSAIDs = non-steroidal anti-inflammatory drugs.