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. 2018 Jun 15;9:318. doi: 10.3389/fendo.2018.00318

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Copyright © 2018 Syro, Rotondo, Camargo, Ortiz, Serna and Kovacs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Sites of alkylation on the various bases in the DNA. Temozolomide produces alkylation on position N7 and O6 in guanine and N3 in adenine (blue arrows). Other alkylating agents act on different sites of alkylation (small gray arrows). (B) Chemical stability, mutagenesis, cytotoxicity, and repair mechanisms in different sites of alkylation. Based on Ref. (8, 9, 16, 19). Abbreviations: BER, base excision repair; DR, direct repair; MMR, mismatch repair; NER, nucleotide excision repair; DNA, deoxyribonucleic acid.