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Schematic of mode of action of temozolomide (TMZ). The activation of TMZ in physiologic pH levels within the blood stream into its reactive state that is responsible for methylating DNA. Based on Ref. (8, 19, 23). Abbreviations: MTIC, 5-(3-monomethyl-1-triazeno) imidazole-4-carboxamide; AIC, 5-aminoimidazole-4-carboxamide; MGMT, O6-methylguanine-DNA methyltransferase.
