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. 2018 Jun 15;11:194. doi: 10.3389/fnmol.2018.00194

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Copyright © 2018 Shi, Li and Shao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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dsh-2/Dvl and sys-1/β-catenin are required for AIY synaptic clustering. (A–C) Confocal micrographs of the AIY presynaptic pattern of GFP::RAB-3 marker in animals treated with control (A), dsh-2 (B) or sys-1 (C) RNAi. The GFP::RAB-3 clustering is normal in control RNAi group, but broken into multiple pieces in dsh-2 (B) or sys-1 (C) RNAi group. Dashed boxes highlight AIY Zone 2 and asterisks indicate the position of AIY soma. Scale bar: 10 μm. (D,E) Quantification of AIY Zone 2 fragmentation in bar-1(mu63), dsh-1(ok1445) mutants, or mig-5, hmp-2, wrm-1, dsh-2 and sys-1 knockdown (D), or knockdown of dsh-2 or sys-1 in cwn-2(ok895) or cfz-2(ok1202) (E). Data indicate that dsh-2 and sys-1 are required for AIY presynaptic assembly and act in the cwn-2/cfz-2 pathway. ns: not significance, ***p < 0.001, ****p < 0.0001 analyzed by one-way ANOVA Dunnett’s test. Error bars represent 95% confidence interval.