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. 2018 Jun 15;9:631. doi: 10.3389/fphar.2018.00631

Figure 1.

Figure 1

The antidepressant- and anxiolytic-like effects of trans-Resveratrol on mice exposed to chronic-acute combined stress (CACS). Mice were exposed to stress (subjected to CACS) and daily treated with vehicle (Veh), trans-Resveratrol (Resv, 2.5, 5.0 and 10.0 mg/kg, i.g.), rolipram (Rol, 1.25 mg/kg, i.p.) or desipramine (Des, 0.5 mg/kg, i.p.) in SPT and FST, or diazepam (Dia, 10 mg/kg, i.p.) in OFT and EPM 30 min before stress for 3 weeks. The sucrose preference ratio was measured in sucrose preference test (SPT) on day 0 and day 20 (A,B, respectively). Immobility time was measured in forced swimming test (FST) on day 21 (C). The distance in the center area, time spent in the center area and velocities were measured in the open field test (OFT) on day 21 (D–F). The percentage of open arm entries and the percentage of time spent in open arms were measured in the elevated plus-maze (EPM) test on day 22 (G,H). Results are expressed as mean ± SEM (n = 12). ***P < 0.001 vs. control group (Ctrl), #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. CACS + Veh group.