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. 2018 Jun 15;9:631. doi: 10.3389/fphar.2018.00631

Figure 4.

Figure 4

The intestinal structural changes after treatment with trans-Resveratrol in CACS mice. Mice were exposed to stress (subjected to CACS) and daily treated with vehicle (Veh), trans-Resveratrol (Resv, 2.5, 5.0 and 10.0 mg/kg, i.g.), rolipram (Rol, 1.25 mg/kg, i.p.), desipramine (Des, 0.5 mg/kg, i.p.) or diazepam (Dia, 10 mg/kg, i.p.) 30 min before stress for 3 weeks. (A–F) Photomicrographs of representative HE staining in the ileum. (G–L) Photomicrographs of representative HE staining in the colon. Immune cellular infiltrate is indicated by arrow. Scale bar = 100 μm (A–C, G–I) and 10 μm (D–F, J–L). (M,N) Histopathological scores representing the severity of inflammation were quantified in the ileum and colon. Results are expressed as mean ± SEM (n = 4). ***P < 0.001 vs. Ctrl group, #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. CACS + Veh group.