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. 2018 Jun 15;9:631. doi: 10.3389/fphar.2018.00631

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Copyright © 2018 Xu, Cui, Ma, Shi, Yu, Li, Zheng, Zhang, Si and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immuno-blot analyses for pCREB and BDNF expression in the hippocampus. Mice were exposed to stress (subjected to CACS) and daily treated with vehicle (Veh), trans-Resveratrol (Resv, 2.5, 5.0, and 10.0 mg/kg, i.g.), rolipram (Rol, 1.25 mg/kg, i.p.), desipramine (Des, 0.5 mg/kg, i.p.) or diazepam (Dia, 10 mg/kg, i.p.) 30 min before stress for 3 weeks. (A) Photomicrographs of representative immune-blotting bands; (B–D) PDE4A expression, the ratio of pCREB to total CREB and BDNF protein levels in the hippocampus were measured. Results are expressed as mean ± SEM (n = 8). ^***P < 0.001 vs. Ctrl group, ^#P < 0.05, ^##P < 0.01 and ^###P < 0.001 vs. CACS + Veh group.