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. 2018 Jun 15;9:420. doi: 10.3389/fneur.2018.00420

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Copyright © 2018 Tully, Tang, Zheng, Acosta, Tian, Hayward, Race, Mattson and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of 3-HPMA levels in urine and acrolein-lysine adducts in spinal cord tissue of EAE mice. The urine 3-HPMA is plotted against tissue acrolein-lysine adducts for 9 EAE mice showing the relationship between these two parameters. As indicated, the increase of urine 3-HPMA correlated with the elevation of tissue acrolein-lysine adducts. Statistical analysis of correlation revealed a Pearson correlation coefficient (r) value of 0.87 (p < 0.005, two tailed).