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. 2018 Jun 15;9:1371. doi: 10.3389/fimmu.2018.01371

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Copyright © 2018 Espinosa, Mou, Adams, DiBernardo, MacDonald, McRae, Miller, Song, Stempora, Wang, Iwakoshi and Kirk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Terminally differentiated cells arise following multiple infections. Expression of KLRG1 was significantly upregulated on CD4 (p < 0.0126) and CD8 T cells (p < 0.0001, calculated using two-way ANOVA) of mice that received all three infections compared with mice that received mock infections (n = 10 per group).