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. 2018 Jun 15;9:1282. doi: 10.3389/fimmu.2018.01282

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Copyright © 2018 Cox, Danby, Hernandez, Laza-Briviesca, Pearson, Madrigal and Saudemont.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of MHC class I-related chain A (MICA) transmembrane (TM) polymorphism on sMICA levels detected in umbilical cord blood (UCB) plasma samples. UCB samples were stratified according to the number of alanine residues encoded by GCT triplet (Ala) repeats in exon 5 of the MICA gene. (A) Heterozygous allele combinations with any other allele. (B) Heterozygous allele combinations with A5.1, which associates with MICA*008 with high frequency. (C) Homozygous TM polymorphism. Data represent MICA typing and ELISA measurement of sMICA obtained from 181 cord blood samples. Statistical analysis was performed using Kruskal–Wallis test with Dunn’s post hoc test ± SEM (*P ≤ 0.05, **P < 0.01, and ****P < 0.0001).