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. 2018 Jun 15;9:1282. doi: 10.3389/fimmu.2018.01282

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Copyright © 2018 Cox, Danby, Hernandez, Laza-Briviesca, Pearson, Madrigal and Saudemont.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional analysis of MHC class I-related chain A (MICA) and MHC class I-related chain B (MICB) promoter regions. 5′UTR polymorphic nucleotides associated with each type of MICA/B promoter are shown on the left and fold transcriptional activity relative to SV40 promoter is shown alongside. Quiescent HCT116 cells were grown to over-confluence for 7-day post-transfection before being heat-shock-treated (black/green bars) or isotype-treated without heat-shock (white bars). Fold-difference relative to SV40 control plasmid transfection is indicated. Assay conditions were performed in triplicate with three independent preparations of plasmid construct DNA and repeated for a total of four independent experiments. Nucleotide positions relative to ATG start codon are indicated for each polymorphic position. Abbreviations: UTR, untranslated region; LUC, luciferase gene.