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. 2018 Jun 15;9:1282. doi: 10.3389/fimmu.2018.01282

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Copyright © 2018 Cox, Danby, Hernandez, Laza-Briviesca, Pearson, Madrigal and Saudemont.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of relative luciferase transcription potential of MHC class I-related chain A (MICA)/MHC class I-related chain B (MICB) promoter types in proliferating and heat-shocked HCT116 cells and comparisons with levels of sMICA/B in cord blood. (A) Relative luciferase activity obtained using MICA promoter types. Owing to a lack of MICA homozygotes, heterozygous MICA promoter types were analysed in combination with the highly frequent MICA-P7 for comparison of sMICA levels with transcription levels. (B) Relative luciferase activity obtained using MICB promoter types associated with sMICB levels in homozygous MICB promoter typed cord blood. sMICA/B concentrations were obtained by ELISA for each cord blood plasma sample. Statistical analysis was performed using Kruskal–Wallis test with Dunn’s post hoc test ± SEM (*P ≤ 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).