Fig. 5.

Normalized, infected host trajectories for openmalaria simulations and the semi-analytic Ross/Macdonald model in the text, in three intervention scenarios. For the simulations, these are the normalized proportions of hosts with any parasite density ( ≥ 0.01 parasites/µL). In the left panel of the tryptic, two sets of openmalaria trajectories are displayed, with and without immunity. Eight trajectories for these simulation sets are shown in all cases to demonstrate the implicit stochastic noise. The left panel shows the impact of an MDA campaign deployed at $\tau =10,$ as in cases before. The middle panel shows the impact of an isolated IRS campaign, and the right shows synchronously deployed campaigns. Effective periods of the interventions are highlighted in all panels. The annual EIR is set to ${\mathcal{E}}_a=25$ bites/annum, for $R_0=25,$ a correspondence from ref. [48] and further discussed in Appendix B. The inset shows the corresponding impacts (Eq. (20)) for these three cases, demonstrating the synergy of synchronous deployment. The small error bars on this inset encompass the stochastic variance in I for all simulated trajectories.