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. 2018 Jun 15;9:1329. doi: 10.3389/fimmu.2018.01329

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Copyright © 2018 Walentynowicz, Ochocka, Pasierbinska, Wojnicki, Stepniak, Mieczkowski, Ciechomska and Kaminska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genome-wide comparison of gene expression in microglia in mouse and rat glioma models. Volcano plot of gene expression changes in glioma-associated microglia/macrophages from mouse (A) and rat (B) models. The data for all genes are plotted as log2 fold change between microglia and control samples versus the −log10 of the corresponding adjusted p-values. Genes selected as significantly different are highlighted as red dots. Venn diagram for overlap of genes upregulated in mouse (left) and rat (right) model (C). Enrichment analysis of Gene Ontology terms within mouse (D) and rat (E) upregulated genes. Bar plots represent the statistical significance of the enrichment [−log10 (p-val)] (D,E).