FIG 2.

Testing the protective efficacy of the four modified ChAdOx1 vaccine candidates against M. tuberculosis infection. (a) Experimental schema. ifu, infectious units; CFU, colony-forming units. (b and c) Lung (b) and spleen (c) bacterial loads of naive and vaccinated CB6F1 mice after aerosol M. tuberculosis Erdman infection. Vaccinated mice received a single i.n. ChAdOx1 vaccination. 3+12+51+15 represents a group of animals that received the four viruses in one administration (n = 8 mice). Representative data from one of two duplicate experiments are shown. Each symbol represents one animal, and the lines represent the median for each group. The Kruskal-Wallis test followed by Dunn's multiple-comparison test was used to test for significant differences. *, P < 0.05; **, P < 0.01; ****, P < 0.0001.