FIG 3.

Assessing the ability of ChAdOx1 candidate vaccines to improve the protective efficacy of BCG. (a) Experimental schema used to immunize CB6F1 mice. (b and c) Lung (b) and spleen (c) bacterial loads were measured 4 weeks after aerosol M. tuberculosis infection. Each symbol represents one animal, and the lines represent the median for each group (n = 8 mice). The Kruskal-Wallis test followed by Dunn's multiple-comparison test was used to test for significant differences. **, P < 0.01; ***, P < 0.001. The findings were confirmed by five independent experiments.