FIG 4.

Measurement of the breadth and strength of the immune response induced after administration of the different ChAdOx1 vaccines. The antigen-specific IFN-γ immune responses in BALB/c and C57BL/6 mice were measured at 2 weeks postimmunization. (a and b) ChAdOx1.PPE15 vaccination; (c and d) ChAdOx1.PPE51 vaccination; (e and f) ChAdOx1.PE3 vaccination; (g and h) ChAdOx1.PE12 vaccination. Splenocytes from three vaccinated animals were stimulated with pools of 10 15-mer peptides overlapping by 11 amino acids. Each dot represents one animal, and the lines represent the median response. Data are representative of those from two independent experiments.