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Recognition of the immunodominant epitopes of PPE15 during natural M. tuberculosis infection. CB6F1 mice were challenged with M. tuberculosis, and lung (a and b) and spleen (c and d) cells were collected at 4 weeks postinfection. Cells were stimulated with the immunodominant epitopes, and the percentage of cytokine-secreting CD4+ and CD8+ T cells was measured. The bars represent the median values for three animals, and the lines above the bars represent the intermediate ranges.
