FIG 6.

Acidic mammalian chitinase contributes to worse lung function during fungal asthma. (A and B) WT and Chia^−/− mice were subjected to experimental fungal asthma. Twenty-four hours after the last organism challenge, dynamic lung resistance (A) and airway resistance (B) were analyzed via mechanical ventilation using the flexiVent system. Shown are cumulative data from two independent studies (n = 5 mice per group, per study). Data are expressed as means ± standard errors of the means. (C) Representative periodic acid-Schiff-stained lung sections from WT (top images) and Chia^−/− (bottom images) mice. Original magnification, ×200. Bar, 100 μm. For all graphs, ** and *** represent P values of <0.01 and 0.001, respectively (2-way analysis of variance).