FIG 6.

Myeloid-derived arginase-1 contributes to S. aureus clearance during subcutaneous abscess infection. Subcutaneous abscesses were established in Arg-1^fl/fl;Tie-2^null (WT) and Arg-1^fl/fl;Tie-2^Cre mice following inoculation with 10⁷ CFU S. aureus LAC. Animals were sacrificed at days 3, 7, and 10 postinfection, whereupon abscess-associated bacterial burdens (A) and leukocyte infiltrates (C to F) were measured. (B) Abscess sizes were monitored by use of calipers throughout the course of infection. Results are representative of two independent experiments. *, P < 0.05; **, P < 0.01 (unpaired 2-tailed Student's t test).