FIG 1.

C. muridarum CM001 intravaginal infection disseminates to distal organs in wild-type mice and is rapidly cleared. (A) C57BL/6J mice were intravaginally infected with Nigg or C. muridarum clones, and the course of primary infection was monitored with lower genital tract swab specimens. Significance was determined by two-way RM ANOVA. Data represent the mean + SD for swab specimens from infected mice or swab specimens from infected and uninfected mice (n = 4 mice per group). P values for comparison of the groups over the primary infection course were as follows: P = 0.02 for Nigg versus CM001 and P = 0.05 for Nigg versus CM012. (B) CM001 and Nigg lung, spleen, and oviduct burdens were compared by determination of the numbers of PFU on the indicated days postinfection. Statistical significance, determined by two-way ANOVA, is indicated by asterisks, as follows: *, P < 0.05; ***, P < 0.001.