FIG 3.

In vitro traversal and invasion inhibition of homologous P. falciparum NF54 sporozoites by CPS-induced antibodies in the presence or absence of complement. (A and B) The percent inhibition of traversal (14 volunteers) (A) and invasion (17 volunteers) (B) was calculated for 10% postimmunization serum compared to preimmunization serum for each volunteer in the presence of 10% inactive or active complement. (C) Spearman correlation analysis between cumulative parasitemia (P. falciparum parasites per milliliter) during three CPS immunizations and invasion inhibition by CPS-induced antibodies (Abs) in the presence of active complement (uncorrected for HIS) (n = 17 volunteers). Data are shown as the means of results from duplicate measurements and presented as black squares or gray circles for samples tested in the presence of inactive or active complement, respectively.