TABLE 2.
Genes of the epithelial growth and proliferation family (GO:0050673) altered by IL-22 in IAV-infected micea
| Gene symbol | Fold increase | Nameb | Function(s) | Role(s) in the lungc |
|---|---|---|---|---|
| Fgf9 | 2.2 | Fibroblast growth factor 9 | Cell differentiation, antiapoptotic | Development, organogenesis, antifibrotic, repair |
| Fgfr4 | 2.4 | Fibroblast growth factor receptor 4 | Epithelial-mesenchymal transition | Alveolar development, repair (?) |
| Gdf5 | 3.2 | Growth differentiation factor 5 (TGF-β family) | Cell differentiation, angiogenesis, antiapoptotic | Unknown |
| Ptn | 7.5 | Pleiotrophin (related to midkine) | Cell differentiation, angiogenesis | Fetal development |
| Bmp10 | 3.4 | Bone morphogenetic protein 10 (TGF-β family) | Endothelial homeostasis, angiogenesis | Fetal development (?) |
| Bmpr2 | 7 | Bone morphogenetic protein receptor 2 (TGF-β family) | Tissue remodeling | Arterial hypertension |
| Lgr5 | 7.7 | Leucine-rich repeat-containing G protein-coupled receptor 5 | Marker of adult stem cells (epithelial tissues) | Morphological structure, alveoli and bronchi |
| Efna2 | 8.3 | Ephrin A2 | Angiogenesis, vascular permeability | Lung inflammation |
| Sema5a | 2.2 | Sema domain 7, thrombospondin repeats, TM domain, short cytoplasmic domain 5A | Development biology, axonal guidance | Prognostic biomarker for lung cancer |
| Sox5 | 3.4 | Sex determining region Y-box 5 | Epithelial-mesenchymal transition | Development |
| Vash1 | 3.4 | Vasohibin 1 | Inhibits angiogenesis | Reduces bronchiolitis |
| Kif3c | 4.4 | Kinesin family member 3C | Microtubule dynamic, ciliogenesis | Epithelial-mesenchymal transition |
| Col25a1 | 5 | Collagen type 25α1 | Basement membrane, structure (brain) | Unknown |
a
Gene expression was assessed at 8 h.
b
TM, transmembrane.
c
Uncertain roles are indicated with a question mark.