Table 2. Gene frequencies of the EBF1 gene, SNPs sites, and their relationship with the risk of CAD.
| SNPs | CAD group (n=243) | Control group (n=215) | OR (95% CI) | P value | Adjusted OR (95% CI) | P value |
|---|---|---|---|---|---|---|
| rs987401919 | ||||||
| Genotype | ||||||
| CC | 177 (72.84%) | 178 (82.79%) | Ref | |||
| CT | 54 (22.22%) | 29 (13.49%) | 1.873(1.108–3.174) | 0.013 | 1.305(1049–1.558) | 0.018 |
| TT | 12 (4.94%) | 8 (3.72%) | 1.508(0.558–4.151) | 0.377 | 1.203(0.721–1.637) | 0.514 |
| Alleles | ||||||
| C | 408 (83.95%) | 385 (89.53%) | Ref | |||
| T | 78 (16.05%) | 45 (10.47%) | 1.636(1.085–2.468) | 0.013 | 1.233(1.039–1.421) | 0.017 |
| rs36071027 | ||||||
| Genotype | ||||||
| CC | 170 (69.96%) | 172 (80.00%) | Ref | |||
| CT | 56 (23.05%) | 37 (17.21%) | 1.531(0.937–2.507) | 0.072 | 1.211(0.99–1.464) | 0.093 |
| TT | 17 (7.00%) | 6 (2.79%) | ||||
| Alleles | ||||||
| C | 396 (81.48%) | 381 (88.60%) | Ref | |||
| T | 90 (18.52%) | 49 (11.40%) | 2.867(1.032–8.353) | 0.025 | 1.487(1.015–1.823) | 0.042 |
| rs1056065671 | ||||||
| Genotype | ||||||
| GG | 182 (74.90%) | 165 (76.74%) | Ref | |||
| GA | 49 (20.16%) | 44 (20.47%) | 1.010(0.623–1.638) | 0.967 | 1005(0.786–1.242) | 0.999 |
| AA | 12 (4.94%) | 6 (2.79%) | 1.813(0.615–5.561) | 0.239 | 1.271(0.775–1.661) | 0.349 |
| Alleles | ||||||
| G | 413 (84.98%) | 374 (86.98%) | Ref | |||
| A | 73 (15.02%) | 56 (13.02%) | 1.180(0.798–1.748) | 0.386 | 1.078(0.895–1.264) | 0.440 |