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Folding of sIBB domains in solution. Circular dichroism analysis of (A) the sIBB domain (residues 1–65 or 25–65) and (B) the αIBB domain (residues 11–54) at pH 7.4. The sIBB domain is partially helical in solution, while the αIBB domain adopts a completely random coil conformation. In both panels A and B, addition of trifluoroethanol (TFE) to a final concentration of 30 or 50% rapidly induced helix formation.
