Fig. 2.

Analysis of therapeutic response defines signature of ADT resistance. (a) Schematic representation of a treatment time-course. Scenario 1: Time to treatment-related event: event occurred during the course of the treatment or within 1.5 years after the treatment end. Time between treatment start and a treatment-related event indicated. Scenario 2: Time to follow-up: time between treatment-start and latest follow-up indicated. (b) ADT response in the TCGA-PRAD cohort. Red vertical bars correspond to time between treatment start and event. Blue circles define censored patients (without events), indicating time between treatment start and latest follow-up. Non-responder (n = 4) and responder (n = 4) (Table S1) patients are indicated. (c) Schematic depiction of the differential methylation signature between non-responder and responder patients, sorted from sites whose methylation did not change (left tail) to sites with significant differential methylation (right tail). Signature was defined as a list of sites ordered by –log10 (p-value) from the two-sample two-tail t-test comparing non-responder and responder patient groups.