Supplementary Fig. 3.

Multimodal analysis of signature thresholds and negative control dataset. (a) Area Under ROC distribution (y-axis) as a function of varying methylation signature threshold (x-axis). (b) Area Under ROC distribution (y-axis) as a function of varying correlation threshold (x-axis). (c) Kaplan-Meier survival analysis on Sboner et al dataset demonstrates that therapeutic predictive ability of the identified 5 site-gene panel is independent of disease progression. Log-rank p-value and hazard ratio are indicated.