Table 2B.
Human genes downregulated after 2 h Infection with S. Typhi.
| Feature.ID | p.Value | LFC infected/control | Gene name | Function description (from uniprot) |
|---|---|---|---|---|
| Significant genes (P-value < 0.005 and log fold change (LFC) > 1.5) | ||||
| ENSG00000242512 | 3.15E-06 | −4.03 | LINC01206 | Unknown |
| ENSG00000139304 | 5.61E-05 | −3.87 | PTPRQ | Dephosphorylates a broad range of phosphatidylinositol phosphates. |
| ENSG00000140798 | 4.56E-05 | −3.67 | ABCC12 | Probable transporter. |
| ENSG00000172995 | 1.64E-05 | −3.49 | ARPP21 | Calmodulin binding protein |
| ENSG00000280065 | 1.87E-11 | −3.31 | Unknown | |
| ENSG00000081479 | 8.79E-08 | −3.3 | LRP2 | Acts together with CUBN to mediate HDL endocytosis (By similarity).* |
| ENSG00000178568 | 1.65E-05 | −3.21 | ERBB4 | Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. |
| ENSG00000163554 | 7.66E-05 | −3.2 | SPTA1 | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane.* |
| ENSG00000140538 | 3.83E-10 | −3.15 | NTRK3 | NTRK3 auto-phosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| ENSG00000232111 | 4.22E-05 | −3.13 | RP11-126O22.1 | Novel processed pseudogene |
| ENSG00000279003 | 2.15E-08 | −3.09 | ENSG00000279003 | Unknown |
| ENSG00000263006 | 1.26E-05 | −3.06 | ROCK1P1 | Transcribed unprocessed pseudogene |
| ENSG00000279185 | 1.51E-06 | −3 | ENSG00000279185 | Unknown |
| ENSG00000181143 | 3.26E-14 | −2.99 | MUC16 | Thought to provide a protective barrier against particles and infectious agents at mucosal surfaces |
| ENSG00000169436 | 4.07E-06 | −2.91 | COL22A1 | Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. |
| ENSG00000140465 | 5.12E-06 | −2.84 | CYP1A1 | Heme-thiolate monooxygenases.* |
| ENSG00000039139 | 2.86E-06 | −2.83 | DNAH5 | Force generating protein of respiratory cilia. Produces force toward the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. |
| ENSG00000205592 | 5.15E-08 | −2.83 | muc19 | May function in ocular mucus homeostasis. |
| ENSG00000148053 | 7.87E-08 | −2.82 | NTRK2 | Receptor tyrosine kinase |
| ENSG00000279184 | 8.78E-11 | −2.8 | RP3-323A16.1 | Unknown |
| ENSG00000007174 | 2.85E-07 | −2.79 | DNAH9 | Force generating protein of respiratory cilia. Produces force toward the minus ends of microtubules. |
| ENSG00000166923 | 5.46E-12 | −2.75 | GREM1 | Cytokine |
| ENSG00000186487 | 1.69E-05 | −2.74 | MYT1L | May function as a pan neural transcription factor associated with neuronal differentiation. |
| ENSG00000127241 | 5.72E-06 | −2.74 | MASP1 | Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. |
| ENSG00000172724 | 1.09E-05 | −2.73 | CCL19 | May play a role in inflammatory and immunological responses and in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. |
| ENSG00000137077 | 1.23E-13 | −2.7 | CCL21 | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity toward naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. |
| ENSG00000175820 | 1.38E-05 | −2.69 | CCDC168 | Unknown |
| ENSG00000280156 | 8.84E-13 | −2.69 | AC006548.28 | Unknown |
| ENSG00000168702 | 5.33E-05 | −2.68 | LRP1B | Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. |
| ENSG00000165323 | 9.60E-07 | −2.65 | FAT3 | May play a role in the interactions between neurites derived from specific subsets of neurons during development. |
| ENSG00000101638 | 1.22E-05 | −2.64 | ST8SIA5 | This protein is involved in the pathway protein glycosylation, which is part of protein modification. |
| ENSG00000089250 | 3.31E-05 | −2.64 | NOS1 | Produces nitric oxide which is a messenger molecule with diverse functions throughout the body. |
| ENSG00000172023 | 1.92E-11 | −2.54 | REG1B | Uncharacterized protein |
| ENSG00000273079 | 2.60E-08 | −2.51 | GRIN2B | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. |
For the full list of downregulated genes, please see Supplementary Table 1.
For the full list of downregulated genes, please see Supplementary Table 1.