Table 3B.
Select S. Typhi genes downregulated after 2 h Infection.
| Locus | Gene | Log fold change | q-Value | Function |
|---|---|---|---|---|
| T_RS05760 | t1128 | −4.6998 | 0.000303 | Heat-shock protein |
| T_RS20010 | t3935 | −4.68863 | 0.0047827 | Membrane protein |
| T_RS16050 | t3164 | −4.42922 | 0.0356647 | Serine/threonine dehydratase |
| T_RS06575, | t1288 | −4.05222 | 0.0017506 | Type III secretion system protein SsaS |
| T_RS15430 | t3045 | −3.931 | 0.0361737 | Hypothetical protein |
| T_RS14420 | t2844 | −3.85909 | 0.0022412 | Type I-E CRISPR-associated protein Cse1/CasA |
| T_RS09110 | t1790 | −3.82746 | 0.0267944 | N-acetylneuraminate epimerase |
| T_RS01550 | t0307 | −3.74357 | 0.003615 | Anaerobic sulfite reductase subunit B |
| T_RS18320 | t3606 | −3.66574 | 0.0054552 | Hypothetical protein |
| T_RS00180 | t0037 | −3.62981 | 0.0033564 | Sulfatase |
| T_RS23565 | t4633 | −3.62105 | 0.0106418 | Fimbrial chaperone protein |
| T_RS15480 | t3054 | −3.57317 | 0.0234569 | Amidohydrolase |
| T_RS07840 | t1540 | −3.5345 | 0.0046498 | Membrane protein |
| T_RS20210 | t3974 | −3.52218 | 0.0198834 | Ribokinase |
| T_RS09100 | t1788 | −3.50146 | 0.0095141 | MFS transporter |
| T_RS05770 | t1130 | −3.4989 | 0.0031178 | Hypothetical protein |
| T_RS11895 | t2339 | −3.48786 | 0.0253715 | Allantoin permease |
| T_RS06445 | t1262 | −3.42977 | 7.20E-05 | EscC/YscC/HrcC family type III secretion system outer membrane ring protein |
| T_RS06380 | t1249 | −3.42 | 0.0464325 | Hypothetical protein |
| T_RS02200 | t0435 | −3.39407 | 0.0292125 | Purine-nucleoside phosphorylase |
| T_RS06525 | t1278 | −3.383 | 2.18E-06 | Pathogenicity island protein |
| T_RS09630 | t1891 | −3.37E+00 | 0.0149459 | Hypothetical protein |
| T_RS06460 | t1265 | −3.36098 | 0.0492594 | Chaperone for SseB and SseD |
| T_RS01555 | t0308 | −3.33498 | 0.0106668 | Sulfite reductase subunit alpha |
| T_RS13295 | t2616 | −3.30635 | 0.0073327 | Chaperone protein ClpB |
| T_RS06385 | t1250 | −3.30289 | 0.0493247 | Pseudo hypothetical protein, frameshifted |
| T_RS02205 | t0436 | −3.2902 | 0.016477 | Xanthosine permease |
| T_RS06035 | t1180 | −3.2816 | 0.0254963 | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase |
| T_RS06540 | t1281 | −3.26407 | 5.89E-05 | Type III secretion system protein SsaM, |
| T_RS14505 | t2860 | −3.26E+00 | 0.0025029 | Fimbrial protein SteE |
| lpfA | t3659 | −3.25935 | 0.0271651 | Fimbrial protein |
| T_RS00190 | t0039 | −3.25E+00 | 0.0180323 | Hypothetical protein |
| T_RS23005 | t4522 | −3.09E+00 | 0.0466588 | Polarity suppression protein |
| modA,modB | t2105 | −3.06609 | 0.0034703 | Part of ModCBA molybdate transporter |
| T_RS13735 | t2702 | −3.05094 | 0.0136309 | NrdH-redoxin |
| T_RS20205 | t3973 | −3.05052 | 0.0497433 | Hypothetical protein |
| T_RS11900 | t2340 | −2.99758 | 0.03144 | MFS transporter |
| T_RS06580, | t1289 | −2.95076 | 0.0011772 | Type III secretion system protein SsaT |
| T_RS06555 | t1284 | −2.91116 | 7.20E-05 | SSaO Salmonella pathogenicity island 2 protein |
| T_RS16100 | t3175 | −2.83436 | 0.0014239 | PTS galactitol/fructose transporter subunit II |
| T_RS09515 | t1868 | −2.80141 | 7.14E-05 | Hypothetical protein |
| T_RS15520 | t3062 | −2.79169 | 0.002574 | Molybdenum ABC transporter substrate-binding protein |
| T_RS16110 | t3177 | −2.77916 | 0.0346406 | D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit |
| T_RS21165 | t4162 | −2.7735 | 7.20E-05 | Hypothetical protein |
| T_RS19870 | t3906 | −2.77198 | 0.0376913 | Cyclic-guanylate-specific phosphodiesterase |
| T_RS01545 | t0306 | −2.76366 | 0.0243692 | Sulfite reductase subunit C |
| T_RS23560 | t4632 | −2.75952 | 0.0347524 | Frameshifted |
| T_RS06505 | t1274 | −2.73865 | 0.0360844 | Type III secretion system needle protein SsaG |
| T_RS19490 | t3831 | −2.71975 | 0.0499517 | Hypothetical protein |
| T_RS16450 | t3244 | −2.68263 | 0.011345 | Glutamine amidotransferase |
| T_RS02280 | t0450 | −2.67886 | 0.0466588 | Hypothetical protein |
| T_RS09750 | t1914 | −2.67E+00 | 0.0006626 | Methyltransferase |
| T_RS23210 | t4563 | −2.66886 | 0.0212746 | Membrane protein |
| T_RS23145 | t4550 | −2.6688 | 0.0477512 | SAM-dependent methyltransferase |
| T_RS08510 | t1671 | −2.64519 | 0.0003457 | Nitrate reductase molybdenum cofactor assembly chaperone |
| T_RS06895 | t1352 | −2.6331 | 0.0101017 | Tail fiber protein |
| T_RS14890 | t2935 | −2.6154 | 0.0110453 | Transcriptional regulator |
| T_RS04790 | t0937 | −2.59229 | 0.0423495 | Cell wall hydrolase |
| T_RS18330 | t3608 | −2.58732 | 0.0054552 | Hypothetical protein |
| T_RS07830 | t1538 | −2.56658 | 0.0114123 | ABC transporter ATP-binding protein |
| T_RS18345 | t3610 | −2.48E+00 | 0.000754 | Coproporphyrinogen III oxidase |
| sseA | t1265 | −2.39E+00 | 0.0404711 | Type III secretion system chaperone SseA |
| T_RS12810 | t2522 | −2.27364 | 0.0137239 | Fimbrial chaperone protein |
| T_RS06465 | t1266 | −2.27192 | 0.0169695 | SSeB necessary for the correct localization of SseC and SseD on the bacterial cell surface |
For the full list of downregulated STY genes, please see Supplementary Table 3.
For the full list of downregulated STY genes, please see Supplementary Table 3.