Fig. 3.

Change in serum triglycerides stratified by omega-3 fatty acid supplements and genetic score of omega-3 responsive alleles. Values and error bars are presented as mean and standard error. General linear model was used to estimate the interaction between the total omega-3 fatty acid supplements and a genetic score of omega-3 responsive variants for the change in serum triglycerides (TG, p = 0.04). The genetic score was a sum of the omega-3 responsive allele across the 3 SNPs (rs1527483-G allele, rs1799983-A allele and rs1801282-G allele). Carriers of these alleles in the respective variant showed a better response to omega-3 fatty acids in terms of improved lipid profiles in the present study. High genetic score: score 2–4; low genetic score: score 0–1. *p < 0.05 indicated significant difference in the TG change between different genetic score group among the control group and no significant difference was observed in the other two groups.