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. 2018 Jun 15;9:636. doi: 10.3389/fphar.2018.00636

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Copyright © 2018 Wang, Li, Huang, Su, Chen, Chang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac function parameters in I-R rats treated with vehicle or lumbrokinase. Post-ischemic treatment with vehicle or lumbrokinase (10 μg/kg) in rats subjected to myocardial I-R injury. (A) Mean blood pressure, (B) heart rate, (C) LVSP, (D) LVDP, (E) max dP/dt, and (F) min dP/dt were determined before CAO (baseline), 30 min after CAO (CAO 30 min), and 180 min after reperfusion (CAR 180 min). Each value is represented as the mean ± SEM (n = 4–8). ^∗p < 0.05 compared with the sham group; ^#p < 0.05 compared with the vehicle group.