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. 2018 Jun 15;9:636. doi: 10.3389/fphar.2018.00636

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Copyright © 2018 Wang, Li, Huang, Su, Chen, Chang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Post-ischemic lumbrokinase treatment activated Sirt1 after myocardial I-R injury. Post-ischemic treatment with vehicle or lumbrokinase (10 μg/kg) in rats subjected to myocardial I-R injury. (A) Representative images of the Western blot results. Quantitative densitometric analysis of (B) Sirt1 protein expression and (C) the ratio of Ac-FoxO1 to FoxO1 in rat myocardium after myocardial I-R injury. Data are normalized with values from the sham group and presented as percentage rates. Each value is represented as the mean ± SEM (n = 3). ^∗p < 0.05 compared with the sham group; ^#p < 0.05 compared with the vehicle group.