Table 1.
Effects of post-ischemic lumbrokinase treatment in rats subjected to myocardial I-R injury.
| Sham (n = 6) | Vehicle (n = 13) | LK (n = 13) | ||
|---|---|---|---|---|
| Myocardial Infarction | ||||
| Ventricle (g) | 0.78 ± 0.07 | 0.87 ± 0.05 | 0.86 ± 0.02 | |
| AAR (g) | – | 0.55 ± 0.01 | 0.57 ± 0.01 | |
| AAR/Ventricle (%) | – | 63.8 ± 2.89 | 65.8 ± 0.69 | |
| Infarct (g) | – | 0.13 ± 0.004 | 0.11 ± 0.003# | |
| Infarct/AAR (%) | – | 23.6 ± 0.96 | 19.6 ± 0.59# | |
| Cardiac Biomarkers | ||||
| LDH (U/L) | 1083.0 ± 229.6 | 4290.0 ± 940.4∗ | 3125.3 ± 577.4# | |
| CK-MB (U/L) | 4525.5 ± 1548.5 | 10053.6 ± 1285.9∗ | 7209.8 ± 984.9# | |
| Troponin-I (ng/mL) | 1.07 ± 0.68 | 189.29 ± 52.68∗ | 39.44 ± 19.00# | |
| Arrthymias | ||||
| VT | Incidence (%) | – | 86 | 46# |
| Duration (sec) | – | 26.4 ± 8.4 | 3.8 ± 1.8# | |
| VF | Incidence (%) | – | 36 | 8 |
| Duration (sec) | – | 19.8 ± 8.6 | 0.9 ± 0.9# | |
AAR, area at risk; LDH, lactate dehydrogenase; CK-MB, creatine kinase-MB; VT, ventricular tachycardia; VF, ventricular fibrillation. Values are shown as the mean ± SEM. ∗p < 0.05 compared with sham; #p < 0.05 compared with vehicle.