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. 2018 Jun 22;13:32. doi: 10.1186/s13024-018-0264-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Tmem106b Reduction Does Not Rescue the Social Dominance Deficits of Grn^+/− Mice. When paired against Grn^+/+:Tmem^+/+ mice, Grn^+/−:Tmem^+/+ mice exhibited the expected losing phenotype as shown by both wins per genotype (a, Binomial test, p = 0.0053, n = 133 matches) and winning percentage (b, Mann-Whitney test, p = 0.0016, n = 45–46 mice per genotype). Grn^+/−:Tmem^+/− mice also exhibited a losing phenotype versus Grn^+/+:Tmem^+/+ mice (c, Binomial test, p < 0.0001, d, Mann-Whitney test, p < 0.0001, n = 30 mice per genotype). Tmem106b reduction did not i change social dominance between either Grn^+/− mice(h, Binomial test, p = 0.6879, i, Mann-Whitney test, p = 0.6198, n = 33 mice per genotype) or Grn^+/+ mice (f, Binomial test, p > 0.9999 g, Mann-Whitney test, p = 0.6914, n = 11 mice per genotype)