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. 2018 Jun 22;13:32. doi: 10.1186/s13024-018-0264-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Increased Enzyme Activity is Associated with Increased Enzyme Levels in Grn^+/− and Grn^−/− Mice. Grn^−/− mice exhibited elevated HexA activity in the frontal cortex at age 2–3 months (a, ANOVA effect of Grn, p < 0.0001, Dunnett’s post-hoc test, p = 0.0001), which was associated with reduced HexA protein levels (b, ANOVA effect of Grn, p = 0.0003, Dunnett’s post-hoc test, p = 0.0007). While Grn^+/− mice did not exhibit elevated HexA activity at 2–3 months of age, 20 month-old Grn^+/− mice exhibited elevated HexA (a, t test, p = 0.037) and GCase (c, t test, p = 0.0408) activity in the frontal cortex. Consistent with this increased activity, Grn^+/− mice exhibited elevated HexA (b, t test, p = 0.0262) and GCase (d, t test, p = 0.0222) protein levels. * = p < 0.05, *** = p < 0.001, **** = p < 0.0001. n = 8–19 mice per genotype