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. 2018 May 4;31:226–242. doi: 10.1016/j.ebiom.2018.04.024

Fig. 4.

Fig. 4

Prednisolone treatment improves disease phenotypes in severe SMA mice. qPCR analysis of (a)Nr3c1, (b) GRα and GRβ (c) Klf15 and (d) Bcat2 mRNAs in tibialis anterior (TA) muscle of post-natal day (P) 2 and P7 untreated and prednisolone-treated Smn−/−;SMN2 mice and control littermates. a-d: Data represent mean ± SD; n = 3–4 animals per group; two-way ANOVA; *p < 0.05, **p < 0.01, ****p < 0.0001; ns = not significant. e. Weight curves of prednisolone-treated Smn−/−;SMN2 mice vs. untreated animals. Data represent mean ± SD; n = 10–16 animals per group; *p < 0.05, **p < 0.01. f. Lifespan of prednisolone-treated Smn−/−;SMN2 mice vs. untreated animals. Data represent Kaplan-Meier curves; n = 10–16 animals per group; Log-rank (Mantel-Cox) test; p = 0.0009. g. Weight curves of prednisolone-treated healthy controls vs. untreated animals. Data represent mean ± SD; n = 9–18 animals per group; ****p < 0.0001.